Course contents:

  1. Introduction (FR1)
    • Current Status of Radicals
    • Chemistry What is a Radical
    • Free Radicals and Life
  2. Historical Aspects (FR2)
  3. Electronic Structure and Bonding (FR3)
  4. Active Oxygen Specie (FR4)
    • O2, O2•-·, HO2•, 1O2, H2O2, HO•
    • Chemistry
    • H2O2 and peroxides
  5. Radical Reactions 
    • Atom transfer (FR5a)
    • Addition to multiple bonds (FR5b)
    • Homolytic Aromatic Substitution (FR5c)
    • Electron Transfer (oxidation-reduction) (FR5d)
  6. Thermodynamics (FR6)
  7. Free Radical Kinetics (FR7)
    • First-order FR Reaction
    • Second-order FR Reaction
    • Steady state approximation
    • Free-radical chain reactions
    • Redox chain reactions
    • Inhibition in radical reactions
  8. Radiation Chemistry (FR8)
    • Tools
    • Species: e–aq, H•, HO•, H2O2, H2, O2•−
    • Pulse Radiolysis/Flash Photolysis
  9. Lipid Peroxidation (FR9)
    • Chemistry
    • Analytical tools
    • Effects
  10. Antioxidants (FR10)
    • Preventive
    • Chain-breaking
    • Small molecules (Vit C/E, CoQ, Urate).
    • Enzymes
    • Chelates
  11. Iron and Free Radical Chemistry (FR11)
    • Iron Catalyzed Reactions
    • Iron Complexes
  12. Radicals involving DNA and Proteins (FR12)
  13. Radicals in Photochemistry (FR13)
    • Photochemistry
    • Photosensitization
  14. Detection of Radicals (FR14)
    • TBARS
    • Fluorescence
    • Cyt C /NBT
    • Chemiluminescence
  15. Electron Paramagnetic Resonance (EPR) (FR15)
    • Direct Detection
    • Spin Trapping
    • Transition metal
  16. Reactive Nitrogen Species (RNS) (FR16)
  17. Reactive Oxygen Species (ROS) (FR17)